Corticosteroid therapy for patients with COVID-19 pneumonia: a before-after study.
Identifieur interne : 001212 ( Main/Exploration ); précédent : 001211; suivant : 001213Corticosteroid therapy for patients with COVID-19 pneumonia: a before-after study.
Auteurs : Firouzé Bani-Sadr [France] ; Maxime Hentzien [France] ; Madeline Pascard [France] ; Yohan N'Guyen [France] ; Amélie Servettaz [France] ; Laurent Andreoletti [France] ; Lukshe Kanagaratnam [France] ; Damien Jolly [France]Source :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2020.
Descripteurs français
- KwdFr :
- Betacoronavirus (isolement et purification), Femelle (MeSH), Hormones corticosurrénaliennes (usage thérapeutique), Humains (MeSH), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Mortalité hospitalière (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH).
- MESH :
- isolement et purification : Betacoronavirus.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Hormones corticosurrénaliennes.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Femelle, Humains, Mortalité hospitalière, Mâle, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (isolation & purification), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology).
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Aged, Aged, 80 and over, Female, Hospital Mortality, Humans, Male, Pandemics.
Abstract
Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death or intensive care unit (ICU) admission. A before-after study was performed to evaluate the effect of addition of corticosteroids to our institution's COVID-19 treatment protocol on hospital mortality. A total of 257 patients with a COVID-19 diagnosis were included in this study between 3 March 2020 and 14 April 2020. As corticosteroids were widely used after 27 March 2020, two periods were considered for the purposes of this study: the 'before' period from 3-20 March 2020 (n = 85); and the 'after' period from 26 March-14 April 2020 (n = 172). The 'after' period was associated with a lower risk of death [adjusted hazard ratio (aHR) = 0.47, 95% confidence interval (CI) 0.23-0.97; P = 0.04] and a lower risk of ICU admission or of death before ICU admission (aHR = 0.37, 95% CI 0.21-0.64; P = 0.0005) by multivariate analysis adjusted for age, National Early Warning score and institutionalisation status. In conclusion, addition of corticosteroids to our institution's COVID-19 treatment protocol was associated with a significant reduction in hospital mortality in the 'after' period.
DOI: 10.1016/j.ijantimicag.2020.106077
PubMed: 32634602
PubMed Central: PMC7342082
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Diseases, Reims University Hospital, Reims, France. Electronic address: fbanisadr@chu-reims.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Hentzien, Maxime" sort="Hentzien, Maxime" uniqKey="Hentzien M" first="Maxime" last="Hentzien">Maxime Hentzien</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region 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University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Servettaz, Amelie" sort="Servettaz, Amelie" uniqKey="Servettaz A" first="Amélie" last="Servettaz">Amélie Servettaz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Andreoletti, Laurent" sort="Andreoletti, Laurent" uniqKey="Andreoletti L" first="Laurent" last="Andreoletti">Laurent Andreoletti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Kanagaratnam, Lukshe" sort="Kanagaratnam, Lukshe" uniqKey="Kanagaratnam L" first="Lukshe" last="Kanagaratnam">Lukshe Kanagaratnam</name><affiliation wicri:level="3"><nlm:affiliation>Department of Research and Public Health, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Research and Public Health, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Jolly, Damien" sort="Jolly, Damien" uniqKey="Jolly D" first="Damien" last="Jolly">Damien Jolly</name><affiliation wicri:level="3"><nlm:affiliation>Department of Research and Public Health, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Research and Public Health, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of antimicrobial agents</title><idno type="eISSN">1872-7913</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Pneumonia, Viral (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Betacoronavirus (isolement et purification)</term><term>Femelle (MeSH)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (virologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Male</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death or intensive care unit (ICU) admission. A before-after study was performed to evaluate the effect of addition of corticosteroids to our institution's COVID-19 treatment protocol on hospital mortality. A total of 257 patients with a COVID-19 diagnosis were included in this study between 3 March 2020 and 14 April 2020. As corticosteroids were widely used after 27 March 2020, two periods were considered for the purposes of this study: the 'before' period from 3-20 March 2020 (n = 85); and the 'after' period from 26 March-14 April 2020 (n = 172). The 'after' period was associated with a lower risk of death [adjusted hazard ratio (aHR) = 0.47, 95% confidence interval (CI) 0.23-0.97; P = 0.04] and a lower risk of ICU admission or of death before ICU admission (aHR = 0.37, 95% CI 0.21-0.64; P = 0.0005) by multivariate analysis adjusted for age, National Early Warning score and institutionalisation status. In conclusion, addition of corticosteroids to our institution's COVID-19 treatment protocol was associated with a significant reduction in hospital mortality in the 'after' period.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32634602</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7913</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>2</Issue><PubDate><Year>2020</Year><Month>Aug</Month></PubDate></JournalIssue><Title>International journal of antimicrobial agents</Title><ISOAbbreviation>Int. J. Antimicrob. Agents</ISOAbbreviation></Journal><ArticleTitle>Corticosteroid therapy for patients with COVID-19 pneumonia: a before-after study.</ArticleTitle><Pagination><MedlinePgn>106077</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0924-8579(20)30247-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijantimicag.2020.106077</ELocationID><Abstract><AbstractText>Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death or intensive care unit (ICU) admission. A before-after study was performed to evaluate the effect of addition of corticosteroids to our institution's COVID-19 treatment protocol on hospital mortality. A total of 257 patients with a COVID-19 diagnosis were included in this study between 3 March 2020 and 14 April 2020. As corticosteroids were widely used after 27 March 2020, two periods were considered for the purposes of this study: the 'before' period from 3-20 March 2020 (n = 85); and the 'after' period from 26 March-14 April 2020 (n = 172). The 'after' period was associated with a lower risk of death [adjusted hazard ratio (aHR) = 0.47, 95% confidence interval (CI) 0.23-0.97; P = 0.04] and a lower risk of ICU admission or of death before ICU admission (aHR = 0.37, 95% CI 0.21-0.64; P = 0.0005) by multivariate analysis adjusted for age, National Early Warning score and institutionalisation status. In conclusion, addition of corticosteroids to our institution's COVID-19 treatment protocol was associated with a significant reduction in hospital mortality in the 'after' period.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bani-Sadr</LastName><ForeName>Firouzé</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France. Electronic address: fbanisadr@chu-reims.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hentzien</LastName><ForeName>Maxime</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pascard</LastName><ForeName>Madeline</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Research and Public Health, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>N'Guyen</LastName><ForeName>Yohan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Servettaz</LastName><ForeName>Amélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andreoletti</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Virology, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanagaratnam</LastName><ForeName>Lukshe</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Research and Public Health, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jolly</LastName><ForeName>Damien</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Research and Public Health, Reims University Hospital, Reims, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Antimicrob Agents</MedlineTA><NlmUniqueID>9111860</NlmUniqueID><ISSNLinking>0924-8579</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 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MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">COVID-19 pneumonia</Keyword><Keyword MajorTopicYN="N">Corticosteroid</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32634602</ArticleId><ArticleId IdType="pii">S0924-8579(20)30247-8</ArticleId><ArticleId IdType="doi">10.1016/j.ijantimicag.2020.106077</ArticleId><ArticleId IdType="pmc">PMC7342082</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Champagne-Ardenne</li><li>Grand Est</li></region><settlement><li>Reims</li></settlement></list><tree><country name="France"><region name="Grand Est"><name sortKey="Bani Sadr, Firouze" sort="Bani Sadr, Firouze" uniqKey="Bani Sadr F" first="Firouzé" last="Bani-Sadr">Firouzé Bani-Sadr</name></region><name sortKey="Andreoletti, Laurent" sort="Andreoletti, Laurent" uniqKey="Andreoletti L" first="Laurent" last="Andreoletti">Laurent Andreoletti</name><name sortKey="Hentzien, Maxime" sort="Hentzien, Maxime" uniqKey="Hentzien M" first="Maxime" last="Hentzien">Maxime Hentzien</name><name sortKey="Jolly, Damien" sort="Jolly, Damien" uniqKey="Jolly D" first="Damien" last="Jolly">Damien Jolly</name><name sortKey="Kanagaratnam, Lukshe" sort="Kanagaratnam, Lukshe" uniqKey="Kanagaratnam L" first="Lukshe" last="Kanagaratnam">Lukshe Kanagaratnam</name><name sortKey="N Guyen, Yohan" sort="N Guyen, Yohan" uniqKey="N Guyen Y" first="Yohan" last="N'Guyen">Yohan N'Guyen</name><name sortKey="Pascard, Madeline" sort="Pascard, Madeline" uniqKey="Pascard M" first="Madeline" last="Pascard">Madeline Pascard</name><name sortKey="Servettaz, Amelie" sort="Servettaz, Amelie" uniqKey="Servettaz A" first="Amélie" last="Servettaz">Amélie Servettaz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
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Ou
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{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32634602
|texte= Corticosteroid therapy for patients with COVID-19 pneumonia: a before-after study.
}}
Pour générer des pages wiki
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
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